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Treatment options

Immunological infertility

There are several treatment options available to patients with immunological infertility. Treatment options may include one of the following techniques: antibiotics, intrauterine insemination, drugs, IVF. 

Antibiotics

Antibodies are sometimes produced by men with an infection of the prostate. Long term administration of antibiotics can sometimes result in a significant reduction of antibodies and some pregnancies have been achieved following treatment.

Intrauterine insemination

The intrauterine insemination technique involves washing the sperm free of antibodies and then introducing them into the uterus.

Drugs

Men may be given steroids to suppress the production of antisperm antibodies; they will need to take them for a few months and in high doses. There is a one in three chance of a natural conception. Most pregnancies occur 6-9 months after the treatment. The outcome of the treatment with steroids is unpredictable, as some men may not benefit from it. Treatment with steroids is associated with significant side effects.

IVF

The IVF technique involves washing the sperm and eggs prior to them  mixed together.

Immunotherapy

  • Antiphosphlipid antibodies syndrome or thrombophilia is treated with Heparin and low dose aspirin.
  • HLA DK sharing is treated with lymphocyte immunization treatment (LIT) and Intravenous Immunoglobulin infusion (IVIG).
  • Anti DNA and ANA etc is treated with steroids.
  • Elevated NK cells is treated with IVIG and or Anti-TNF agents (Humira & Enbrel).

Apart from treating antiphospholipids syndrome/ thrombophilia, to date there are no large randomised trials evaluating the benefits and risks of the other treatment modalities mentioned .Furthermore, neither the Royal College of Obstetricians Gynecologists nor the American College of Obstetricians & Gynecologists endorse such treatments.

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Last updated: Sat, 15 Oct 2005 - 0:22:57
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