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Ovulation problems

Details how follicle stimulating hormone (FSH) can be used to induce ovulation by stimulating the ovary to produce multiple follicles.

Ovulation induction by FSH (follicle stimulating hormone)

FSH is given by injection.

The drug FSH is similar to hMG but it contains only the hormone FSH e.g. metrodin. It stimulates the ovaries to produce multiple follicles. HP-FSH is highly purified FSH and can be given subcutaneously by self-injection.

Recombinant FSH is a synthetic FSH produced by recombinant DNA technology and is the latest and purest of the hormones e.g. Gonal F and Puregon (Follistim). It is also given subcutaneously and is at least twice as expensive as urinary FSH.

The use of FSH and hMG should only be performed in clinics that can closely monitor ovarian response; this is because of the increased risk of OHSS and multiple pregnancies. Despite intensive monitoring, multiple pregnancies occur in about 20% of the treatment cycles, of which a third is triplets or more.

The Committee on Safety of Medicines in the United Kingdom has advised that no medical products using urine sourced in a country that has reported cases of human variant CJD (the human form of mad cow disease) be used in the UK.

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