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Ovulation problems
Ovulation induction by FSH
(follicle stimulating hormone)
The drug FSH is similar to hMG
but it contains only the hormone FSH e.g. metrodin. It stimulates the
ovaries to produce multiple follicles. HP-FSH is highly purified FSH and
can be given subcutaneously by self-injection.
Recombinant FSH is a synthetic FSH produced by recombinant
DNA technology and is the latest and purest of the hormones e.g. Gonal
F and Puregon (Follistim). It is also given subcutaneously and is at least
twice as expensive as urinary FSH.
The use of FSH and hMG should only be performed in clinics
that can closely monitor ovarian response; this is because of the increased
risk
of OHSS and multiple
pregnancies. Despite intensive monitoring, multiple pregnancies occur
in about 20% of the treatment cycles, of which a third is triplets or
more.
The Committee on Safety of Medicines in the United Kingdom
has advised that no medical products using urine sourced in a country
that has reported cases of human variant CJD (the human form of mad cow
disease) be used in the UK.
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