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Ovulation problems
Ovulation induction by hCG
(human chorionic gonadotropin hormone)
The drug hCG (human chorionic gonadotropin hormone)
is similar to LH; it is normally produced from
human placenta. It is a highly purified extract from the urine
of pregnant women. It is given in the form of an injection either intramuscularly
or subcutaneously by self-injection e.g. profasi and pregnyl.
The administration of hCG is timed according to the size of the leading
follicles, the development of endometrium as measured by ultrasound
scanning, as well as the levels of estrogen in the blood.
hCG administration helps the follicles to burst and
release the eggs about 36-48 hours after the hormone is given. hCG is
usually given after the woman has already received ovulation drugs such
as Clomiphene, hMG,
FSH or a combination of these drugs.
Ovidrel (Ovitrelle) is the first recombinant human hCG
and is given by subcutaneous rather than intramuscular injection. Recombinant
hCG achieves similar results to urinary hCG in terms of pregnancy rates
and the incidence of OHSS.
However, recombinant hCG is more costly than urinary hCG.
The Committee on Safety of Medicines in the United Kingdom
has advised that no medical products using urine sourced in a country
that has reported cases of human variant CJD (the human form of mad cow
disease) be used in the UK.
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