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Ovulation problems

Details the use of Bromocriptine, Cabergoline and Quinagolide in ovulation induction.


Ovulation induction by Bromocriptine, Cabergoline and Quinagolide

Bromocriptine is given as daily pills

The drugs Bromocriptine, Cabergoline and Quinagolide do not stimulate ovulation by itself, but reduce prolactin secretion. They are prescribed to women who have ovulation problems and are producing excess prolactin. When prolactin levels are normalized, ovulation returns in approximately 90% of women and result in pregnancy in 80-90%.

Bromocriptine has been in clinical use for over 25 years and is given as daily pills. The drug has a well established safety record in pregnancy and long-term follow up of children born to mothers treated with Bromcriptine in early pregnancy are very reassuring. Few patients experience side effects with bromocriptine. The side effects include: nausea, vomiting, dizziness and occasionally blackout. The chance that these symptoms occurring can be reduced by starting the drug a a small dose and gradually build up to a maintenance dose. Prolactin levels need to be checked to confirm that they have been brought down to normal level.

Cabergoline and Quinagolide are longer acting drugs, more efficient and have fewer side effects compared to bromocriptine. A potential shortcoming of Cabergoline is its effect on the heart valve in people who take high doses of the drug. The Committee on Safety of Medicines in the United Kinkdom recommends 6-12 monthly echo of the heart.  

Neither ovarian hyperstimulation syndrome nor an increased risk of multiple pregnancy is a side effect of these drugs.

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