brit1612 wrote:This is my fourth ivf and I was on the boards a lot during my ivf in june. I have been trying to stay away lately so I did not drive myself nuts, but I have a situation that I have never had before.
Today is day 8 of stimulation, and my estrogen level was 2613 and progesterone was 3. They want me to take an antogon (spelling??) shot tonight so that I can go one more day of stims without my levels going to high. I have a few follicles that are ready now, but they think that 4 or 5 more will catch up if we wait one more day before trigger. They seemed to be the most concerned about my progesterone level. I don't know if this is something that can effect the outcome of my cycle. Any input would help.
I can answer some of your question. I'll need more info for the rest.
Antagon (now called ganirelix, or genirelix acetate) is used to prevent ovulation. It's name is derived from the fact that it is a GnRH antagonist. It's GnRH that your hypothalmus releases to signal the pituitary to release an LH surge for ovulation. Antagon blocks that by binding the pituitary receptors.
They are concerned about your levels of progesterone because progesterone starts the endometrium developing, and you have not had your eggs retrieved yet. Progesterone is released in greater amounts after ovulation, and in lesser amounts late in cycles of ovarian stimulation, and they might also be concerned that you may be about to ovulate. It's difficult to read their minds on that one.
Is your progesterone high? Two answers.
1. If you are in the US, and your progesterone is measured in ng/ml, then 3 ng/ml is indeed high, especially considering you are not triggering until tomorrow at least.
2. If you are outside the US, where they probably measure progesterone in nMol/l, then 3 nMol/l is just a little high, but not too bad.
If (1) above is the case, then my clinic would almost certainly freeze all of your embryos for later use with a better endometrium and carefully timed progesterone exposure. If (2) is the case, then have to wait and see what it is tomorrow.
Avoid IVF and surrogacy in Ukraine. Ukrainian centers pay shills to post here under numerous sock accounts pretending to be patients in Ukraine. Centers using such deceptive advertising cannot be trusted and should be avoided.