Flare or antagonist protocal

Discussion forum for those particularly interested in IVF and embryo transfer including frozen embryo transfer.
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Flare or antagonist protocal

Post by *Ert* » Fri May 01, 2009 10:29 pm


I am about the start my second IVF. My first ended in a miscarriage after 8 weeks. I only had 5 mature follicles on the long lupron protocal with nothing left over to freeze. My doctor wants to change it for the next time. She suggested the antagonist protocal. We went for a second opinion and that doctor recommended a flare protocal. He said he does not see as much success with the antagonist as he does with the flare.
Anybody have experience with either of these protocals?


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Location: Lancaster, PA

Post by Neffi211 » Sat May 02, 2009 7:17 pm

Ert-- My first cycle was a flare-- BFN 2nd was antagonist--chemical....thrid also antagonist--BFP DS born 1/23/09 and then my 4th cycle as antagonist BNF.....so I think sometimes it just takes more than one try. Antagonist worked for me, so thats what we'll stick with, but research does favor flare slightly.
Me 32 DH 31
DS 3rd try
8 failed cycles
No luck with adoption
DS 7/23/14 IUI after Celiac diagnosis

Posts: 784
Joined: Mon Aug 18, 2008 8:52 pm

Post by lynniecat » Tue May 05, 2009 9:13 pm

My worst cycle was the antagon cycle, my best was estrogen priming (now 25 weeks).
Me: 44 severely reduced reserve
DH: 44 perfect
IVF 1: Feb 08 -BFP twins (lost one at 7 weeks, one at 13 weeks) :-(
IVF 2: June 08 -BFN :-(
IVF 3: September 08 -BFN :-(
IVF 4: November 08 - Katherine Emma born 8/9/2009 :D

Posts: 520
Joined: Sun Jan 13, 2008 1:19 pm

Post by IndieBlue » Wed May 06, 2009 2:59 pm

My first cycle was the Lupron cycle and I had 7 retrieved, 5 fertilized and 3 transferred on day 3 (all 6 cell or less). It ended in a chemical.

I'm doing antagonist this time which I'm pumped about....because I won't have to do the Lupron and I really think that with my lower count on antral follicles that the less I shut my ovaries down the better.
Me: 34 DH: 37
Tubal Factor IF
1st IVF cycle May/June 2008
Beta #1 6/18 BFN
2nd IVF cycle July 2009
Chemical Pregnancy at 7weeks

Posts: 618
Joined: Tue Feb 06, 2007 9:32 pm

Post by kellym » Wed May 06, 2009 9:45 pm

I did 9 cycles - the first and second one were long protocol (first was a chemical, second was a bfn), the third was a flare cycle which ended up being switched to a IUI because it didn't suppress me and I ovulated, then the rest of them were antagonist (4th was chemical, 5th, 6th, 7th and 8th were all bfn), the last was donor and worked!

I had better success with number of eggs and quality of embryos with the antagonist protocol but as mentioned by Neffi211, I think the flare doesn't get favoured.

Sadly it is all trial and error and you won't know which one works best for you until you try it - I guess that it is the really frustrating part of IVF.
Good luck!!!
7 IVF cycles - 2 chemicals, 5 BFN
1 FET cycle - BFN
9th IVF cycle - BFP!! Twins born Sept 18/08
Trying again May 2010!!!

Warren Dew
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Location: Somerville, MA, USA

Post by Warren Dew » Thu May 07, 2009 3:40 am

We had three lupron cycles that did not work, then one antagonist cycle that worked. My wife had more than twice as many eggs with the antagonist cycle.

That said, different people work respond differently. My wife got very severe headaches from the lupron. Other people do better with lupron cycles.
TTC 2004
2005-2006 - clomid, IUI
mid 2006 - endometriomectomy
Dec 2006 - IVF #1 - negative
Mar 2007 - IVF #2 - chemical
Jun 2007 - IVF #3 - nothing to transfer
Sep 2007 - IVF #4 - healthy baby girl!
Apr 2009 - IVF #5 - healthy baby boy!

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