Ghost

Discussion forum for those particularly interested in IVF and embryo transfer including frozen embryo transfer.
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TammyS
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Posts: 1386
Joined: Sat Dec 29, 2007 10:46 pm
Location: Akron, Ohio

Ghost

Post by TammyS » Thu Feb 03, 2011 3:38 am

Hi Ghost...

My ER is early tomorrow morning...and I'm concerned.

According to my doc, I am having a terrific cycle...but I'm concerned about my E2 level. I had 13 follies growing on my first SnS...and triggered on Tuesday with 9 decent sized follicles...which I figure 7 will likely be mature...8 if we are lucky.

However, my E2 level was only 915. My E2 levels are normally between 1400-1700 each cycle...except with Zach's cycle 3 yrs ago...when it was in the 3000's and we got 12 eggs with 10 mature that cycle.

My lining was only a 10.2 this time ..which I know is fine, but it's normally 12-16 at trigger.

My follies are:
19 (although it was a 20.5 the day before?! Hmm.)
18.5
18
17.5
16
15.5
14
13
12.5

We did a whole new protocol this cycle:
100 mg's of Clomid on days 5-9
100 follistim on days 8-15
Ganerlix on days 11-15

Is it because of the Clomid that my lining and E2 levels are lower than normal?
Do you think we will actually have at least 7 mature follicles despite my E2 level?
Does this indicate that some of my follicles may be empty...though we have never had this issue before?
Do you think maybe we should have waited 1 more day to trigger?

Thanks Ghost.
Me~42/DH~48
3 IUI
IVF 1~1.28.08 Zach
IVF 2~4.5.10 M/C
IVF 3~8.6.10 BFN
IVF 4~9.5.10 M/C
IVF 5~10.30.10 BFN
IVF 6~11.29.10 M/C
IVF 7~2.3.11 M/C
IVF 8~Cancelled
End of the road

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Ghost
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Posts: 4150
Joined: Mon May 29, 2006 5:01 pm

Re: Ghost

Post by Ghost » Thu Feb 03, 2011 4:07 am

TammyS wrote:Hi Ghost...

My ER is early tomorrow morning...and I'm concerned.

According to my doc, I am having a terrific cycle...but I'm concerned about my E2 level. I had 13 follies growing on my first SnS...and triggered on Tuesday with 9 decent sized follicles...which I figure 7 will likely be mature...8 if we are lucky.

However, my E2 level was only 915. My E2 levels are normally between 1400-1700 each cycle...except with Zach's cycle 3 yrs ago...when it was in the 3000's and we got 12 eggs with 10 mature that cycle.

My lining was only a 10.2 this time ..which I know is fine, but it's normally 12-16 at trigger.

My follies are:
19 (although it was a 20.5 the day before?! Hmm.)
18.5
18
17.5
16
15.5
14
13
12.5

We did a whole new protocol this cycle:
100 mg's of Clomid on days 5-9
100 follistim on days 8-15
Ganerlix on days 11-15

Is it because of the Clomid that my lining and E2 levels are lower than normal?
Do you think we will actually have at least 7 mature follicles despite my E2 level?
Does this indicate that some of my follicles may be empty...though we have never had this issue before?
Do you think maybe we should have waited 1 more day to trigger?

Thanks Ghost.
Clomid will not reduce the E2 levels (Letrozole would do exactly that), but it is not as potent a stimulant as Follistim, so the use of Clomid instead of an FSH product may well explain lower E2 than what you had in prior cycles.

Clomid blocks the estradiol receptor, so it may well explain your somewhat thinner endometrium this time.

Your follicle sizes suggest a good chance of about 6 or 7 good eggs.

Not sure if I would have wanted one more day or not.
Avoid IVF and surrogacy in Ukraine. Ukrainian centers pay shills to post here under numerous sock accounts pretending to be patients in Ukraine. Centers using such deceptive advertising cannot be trusted and should be avoided.

TammyS
Valued Contributor
Posts: 1386
Joined: Sat Dec 29, 2007 10:46 pm
Location: Akron, Ohio

Re: Ghost

Post by TammyS » Thu Feb 03, 2011 9:07 am

When you say reduced...you mean go down instead of up? Mine went steadily up...just not up as high as my normal.

Also, since I stimmed 8 days on follistim, but was on Clomid for 4 days leading up to adding follistim (5 days total)...how many days did I technically stimm? 8 or 12? If it is 8...does that seem kinda quick to you...with averages being 10-12 days?

Thanks Ghost!
Me~42/DH~48
3 IUI
IVF 1~1.28.08 Zach
IVF 2~4.5.10 M/C
IVF 3~8.6.10 BFN
IVF 4~9.5.10 M/C
IVF 5~10.30.10 BFN
IVF 6~11.29.10 M/C
IVF 7~2.3.11 M/C
IVF 8~Cancelled
End of the road

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Ghost
Board Veteran
Posts: 4150
Joined: Mon May 29, 2006 5:01 pm

Re: Ghost

Post by Ghost » Thu Feb 03, 2011 3:01 pm

TammyS wrote:When you say reduced...you mean go down instead of up? Mine went steadily up...just not up as high as my normal.
Yes, clomid will not reduce E2 levels, but it usually won't increase them as much as FSH usually does.
Also, since I stimmed 8 days on follistim, but was on Clomid for 4 days leading up to adding follistim (5 days total)...how many days did I technically stimm? 8 or 12? If it is 8...does that seem kinda quick to you...with averages being 10-12 days?

Thanks Ghost!
I'd call it 12 days, but the clomid is a slower stim. It blocks the E2 receptor, so the hypothalamus will release more GnRH to get the pituitary to release more FSH (and LH).

It is believed by some that clomid is bad for endometrial receptivity.
Avoid IVF and surrogacy in Ukraine. Ukrainian centers pay shills to post here under numerous sock accounts pretending to be patients in Ukraine. Centers using such deceptive advertising cannot be trusted and should be avoided.

TammyS
Valued Contributor
Posts: 1386
Joined: Sat Dec 29, 2007 10:46 pm
Location: Akron, Ohio

Re: Ghost

Post by TammyS » Fri Feb 04, 2011 1:38 am

Is it only bad for endometrial receptivity when referring to the lining or what day your cycle is...or other things to?

I am on day 17 of my cycle and ET will be on day 20. My lining was 10.2 at trigger.

Thanks Ghost.
Me~42/DH~48
3 IUI
IVF 1~1.28.08 Zach
IVF 2~4.5.10 M/C
IVF 3~8.6.10 BFN
IVF 4~9.5.10 M/C
IVF 5~10.30.10 BFN
IVF 6~11.29.10 M/C
IVF 7~2.3.11 M/C
IVF 8~Cancelled
End of the road

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Ghost
Board Veteran
Posts: 4150
Joined: Mon May 29, 2006 5:01 pm

Re: Ghost

Post by Ghost » Fri Feb 04, 2011 3:20 am

TammyS wrote:Is it only bad for endometrial receptivity when referring to the lining or what day your cycle is...or other things to?

I am on day 17 of my cycle and ET will be on day 20. My lining was 10.2 at trigger.

Thanks Ghost.
I don't know what the effect is, or if it is reflected in endometrial thickness. I just know the docs I work with say clomid is bad for receptivity.
Avoid IVF and surrogacy in Ukraine. Ukrainian centers pay shills to post here under numerous sock accounts pretending to be patients in Ukraine. Centers using such deceptive advertising cannot be trusted and should be avoided.

TammyS
Valued Contributor
Posts: 1386
Joined: Sat Dec 29, 2007 10:46 pm
Location: Akron, Ohio

Re: Ghost

Post by TammyS » Fri Feb 04, 2011 11:15 am

If you have a moment and can...would you be able to ask? I'm really curious. I have found in my research the same as your saying...but no explanation as to why. I asked my doc...but he keeps saying, it's fine. Thanks Ghost.
Me~42/DH~48
3 IUI
IVF 1~1.28.08 Zach
IVF 2~4.5.10 M/C
IVF 3~8.6.10 BFN
IVF 4~9.5.10 M/C
IVF 5~10.30.10 BFN
IVF 6~11.29.10 M/C
IVF 7~2.3.11 M/C
IVF 8~Cancelled
End of the road

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Ghost
Board Veteran
Posts: 4150
Joined: Mon May 29, 2006 5:01 pm

Re: Ghost

Post by Ghost » Fri Feb 04, 2011 8:38 pm

TammyS wrote:If you have a moment and can...would you be able to ask? I'm really curious. I have found in my research the same as your saying...but no explanation as to why. I asked my doc...but he keeps saying, it's fine. Thanks Ghost.
I asked. The answer was not very specific.

I did a little research. There are reports saying the endometrium is affected in clomid cycles, but there are also reports saying it's not. It may come down to opinion regarding which reports to believe.
Avoid IVF and surrogacy in Ukraine. Ukrainian centers pay shills to post here under numerous sock accounts pretending to be patients in Ukraine. Centers using such deceptive advertising cannot be trusted and should be avoided.

TammyS
Valued Contributor
Posts: 1386
Joined: Sat Dec 29, 2007 10:46 pm
Location: Akron, Ohio

Re: Ghost

Post by TammyS » Sat Feb 05, 2011 3:22 am

Thanks Ghost. I'm finding the same thing. No real reasons as to "why" it affects the endometrium. I really appreciate you going out of your way to ask and do research. You're the best!
Me~42/DH~48
3 IUI
IVF 1~1.28.08 Zach
IVF 2~4.5.10 M/C
IVF 3~8.6.10 BFN
IVF 4~9.5.10 M/C
IVF 5~10.30.10 BFN
IVF 6~11.29.10 M/C
IVF 7~2.3.11 M/C
IVF 8~Cancelled
End of the road

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riogirl71
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Posts: 2518
Joined: Sat Dec 15, 2007 12:10 am
Location: CA, USA

Re: Ghost

Post by riogirl71 » Fri Feb 11, 2011 7:53 pm

Tammy - how are you feeling? How have you been? When is your beta?

TammyS
Valued Contributor
Posts: 1386
Joined: Sat Dec 29, 2007 10:46 pm
Location: Akron, Ohio

Re: Ghost

Post by TammyS » Mon Feb 14, 2011 8:48 pm

Ooops, sorry Rio. Uhm...I'm pregnant!!! lol :D

Thanks again, Ghost! Love you! Happy Valentines Day, Ghost! xoxo
Me~42/DH~48
3 IUI
IVF 1~1.28.08 Zach
IVF 2~4.5.10 M/C
IVF 3~8.6.10 BFN
IVF 4~9.5.10 M/C
IVF 5~10.30.10 BFN
IVF 6~11.29.10 M/C
IVF 7~2.3.11 M/C
IVF 8~Cancelled
End of the road

Image

TammyS
Valued Contributor
Posts: 1386
Joined: Sat Dec 29, 2007 10:46 pm
Location: Akron, Ohio

Re: Ghost

Post by TammyS » Tue Feb 15, 2011 9:37 am

Thanks SD! It's almost your turn!
Me~42/DH~48
3 IUI
IVF 1~1.28.08 Zach
IVF 2~4.5.10 M/C
IVF 3~8.6.10 BFN
IVF 4~9.5.10 M/C
IVF 5~10.30.10 BFN
IVF 6~11.29.10 M/C
IVF 7~2.3.11 M/C
IVF 8~Cancelled
End of the road

Image

Mellie_1233
Regular
Posts: 284
Joined: Wed Sep 26, 2007 9:20 pm
Location: Chicago

Re: Ghost

Post by Mellie_1233 » Fri Feb 18, 2011 10:34 pm

Congratulations on your positive, Tammy! :D :D
ME: 36 DH: 36 - now both 39
DOR

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