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Question for Ghost (or anyone) about immune issues

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Question for Ghost (or anyone) about immune issues

Postby Grey » Fri Jan 25, 2008 11:34 am

I'll try to make my long story relatively short:

We've been TTC nearly 4 years, with 4 failed IUIs. Our first IVF in August 2007 was successful, but I had a missed miscarriage that was found at 11 weeks.

After the miscarriage, I desperately wanted a reason, and asked my RE to do some testing for immune factors. I have an autoimmune disorder, ankylosing spondylitis, which for me is fortunately very mild and mostly just an occasional nuisance. I also have a history of lupus in my extended family (paternal great-aunt). I've always wondered if my infertility might be related to immune issues.

I also had to have a D&C, and we were able to have karyotyping done. That's where I found the reason for the M/C: the baby had Trisomy 13. I started to worry less about immune factors playing a role.

I did get the results back from the immune testing, and everything was in the normal range, with one exception: my IgM and IgG antibody levels were slightly elevated. According to my RE, 10-19 is considered the "low positive" range; my IgM was 11 and my IgG was 10. He said he was personally not concerned since we had found a reason for my M/C and because the levels were so very close to normal. But he did say I could get retested if I wanted to.

Should I be concerned? I'm inclined not to worry about it, but if anyone feels retesting would be called for, I'm willing to do it. If it matters, we're planning on starting Lupron for IVF #2 in late February.

Thanks in advance for any replies!
DH & I both 37
IVF #1 8/2007: BFP, but M/C at 11 weeks due to Trisomy 13
2008: 6 IVFs canceled - poor response
IVF #2 2/2009: 2 embryos transferred, BFN
Mid-2009: 4 more IVFs canceled - poor response
IVF #3 10/2009: BFP, hoping it sticks this time!
Grey
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Posts: 35
Joined: Wed Aug 22, 2007 6:49 pm
Location: Maryland

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