Screening of donors in egg donation

All prospective egg donors both known and anonymous should be screened according to the standards recommended by the regulatory bodies such as HFEA and ASRM in order to avoid the risk of transmission of infection to recipient and offspring and avoid passing on genetic or inherited disease to the offspring. A child born disabled may be able to sue the donor for damages if there is a failure of disclosure of a defect she know or reasonably ought to have known.

Potential donors should be screened for genetic and infectious diseases (HIV, Hepatitis B and C, Cytomegalovirus, syphilis, gonorrhoea and chlamydia), genetic diseases (cystic fibrosis carrier and karyotype) and blood group and Rhesus status. In addition, in appropriate ethnic groups, screening for sickle cell in black donors, thalassemia in Mediterranean and Indian subcontinent donors and Tay-Sachs disease in Jewish donors.

Furthermore, potential egg donor will be screened for ovarian reserve in order to determine the ability of her ovaries to produce eggs. This usually involves blood test to check hormone levels (FSH, LH Estradiol and AMH) and pelvic ultrasound scan to check for antral follicle count. Woman with poor ovarian reserve will not be accepted as egg donors.

There is always the possibility that one or more of these tests may reveal a previously unsuspected condition or infection. We recommend that all prospective donors should consider this very carefully before giving their permission to the tests.

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