A reply for Ghost

[daisy1]

Thanks very much for your input. Unfortunately I never saw your reply until after I`d visited the clinic so never touched on the subject of endometrial receptivity.

I did however have a very long chat with both my gyny and embyologist. Both agree (as you mentioned) that I was still too young for donor eggs, neither however seemed to think that sperm donation was an option just yet and both think that I`m a perfect candidate for pre-implantation genetic screening. I have done minimal if any research into this since talking with them but the extremely general sense I get is that it doesn´t really increase chances of a full term pregnancy and it is very expensive (unfortunately my insurance doesn`t cover any of this) I am hoping that I have completely misunderstood all research papers that I have briefly skimmed over.

What is your opinion of PGS?

What my gyny has decided for definite is change the me to the short cycle as this will apparently increase egg production.

Thanks for your time.

x

[Ghost]

Thanks very much for your input. Unfortunately I never saw your reply until after I`d visited the clinic so never touched on the subject of endometrial receptivity.

I did however have a very long chat with both my gyny and embyologist. Both agree (as you mentioned) that I was still too young for donor eggs, neither however seemed to think that sperm donation was an option just yet and both think that I`m a perfect candidate for pre-implantation genetic screening. I have done minimal if any research into this since talking with them but the extremely general sense I get is that it doesn´t really increase chances of a full term pregnancy and it is very expensive (unfortunately my insurance doesn`t cover any of this) I am hoping that I have completely misunderstood all research papers that I have briefly skimmed over.

What is your opinion of PGS?

What my gyny has decided for definite is change the me to the short cycle as this will apparently increase egg production.

Thanks for your time.

x

I think you got it right.

My opinion is that PGS is not for everybody. In most cases, viable embryos can be chosen morphologically (that is, based on appearance). Also, many patients don't have so many embryos that there is much of a decision in which to transfer. If a patient is among the lucky few with a dozen expanded blastocysts, then choosing the best among them might have value. If they have just one or maybe two, then there is not much of a puzzle regarding which to transfer. So I see it as a potential benefit for good responders only.

Yes, there are studies that show PGD/PGS applied generally can hurt pregnancy rates. It seems to be something that should be used only when indicated in a targeted subset of patients. The best indications seem to be recurrent pregnancy loss in a good responders (see above) and a family history of genetic disease. I would not recommend it for everyone, nor for mere implantation failure.

Of course, some use it for gender selection.