IVF over 40 Buddy Group........Membership Drive

[lynniecat]

Yep Kelly, I read the link.

The thing they did say is if the rapid FISH results had it, but the other tests did not, you had a better chance of CPM. Unfortunately I was the opposite. You know I kept thinking the baby looked weird in the ultrasound compared to last time. Damn, I want to have an ultrasound now ti see if they see anything odd. That will help ease the stress of the next two weeks!

AKMom, its great your friend's baby is fine. I hope I get the same results! I am a little weirded out that they say even with a clean amnio, you may still have a baby with mosaicism. Oh boy...after all this and a freak thing like this happens. To think the embryo started normal and then this!

[Liam'sMommy]

Lynnie, i am a bit confused because the gal in the case had the same history as you. Her preliminary results came back normal but the final report said there were some abnormal placental cells. Isn't that CPM until proven otherwise? The article does not paint that bleak of a outlook for CPM. Also, it could be MCC. The last ultrasound was very early in pregnancy. I certainly would not be able to tell if the baby was normal by looking at it. Heck, i wouldn't be able to tell normal from abnormal in a near term baby. Also, if it was something so abnormal that you could see on an early ultrasound i think your doctor would have said something or the results of the CVS would have been conclusive. I think you have a great chance the baby is healthy.


This little snip it is from Wikipedia.

Also it could just be A small percentage (1-2%) of pregnancies will have confined placental mosaicism, where some but not all of the placental cells tested in the CVS will be abnormal, even though the pregnancy is unaffected.[2] Cells from the mother can be mixed with the placental cells obtained from the CVS procedure. Occasionally if these maternal cells are not completely separated from the placental sample, this can lead to discrepancies with the results. This phenomenon is called Maternal Cell Contamination (MCC).[2] CVS can not detect all birth defects. It's used for testing chromosomal abnormalities or other specific genetic disorders only if there is family history or other reason to test.

I hope you know i am not trying to minimize your fear. But based on what i have read so far i am very hopeful that your little one is going to be just fine. I do agree that you should call your doc and have a repeat US. Have them point everything out to you and tell you if anything looks abnormal.

Also, did POTS sound at all like what you have been experiencing with your health?

Big HUGS. I am sorry you are going through all of this and my prayers are with you.

[lynniecat]

Yes, her case was similar, but the article says if the rapid results are bad and the longer term are good you have a better chance.

Still in all, its more confusing for me as they were not able to tell me what the extra DNA was. Just that its not a known chromosome, but its as big as chromosome 22. They are still working on it. I think that information would really help.

Also with such a low rate, I would think its just placenta, but what do I know. If it happened early on, then there would be more cells derived from the defect. If it happened later, then better chance its just placental cells.


Overall I have a 90 percent good chance. Yeah, the baby probably looked fine, I just thought it looked different than last time. I am sure that means absolutely nothing, but it was in the back of my mind.

The other annoying thing is that although I told DH not to tell anyone the CVS results as they were preliminary. He went and told his parents and told them they were final! Great.....

I think things will be ok, but I need more information. I want to do an ultrasound right away and see if they can see issues, but not sure they will do that...it would help ease my mind.

But the funny thing is, the quad test would have never picked this up...this is one of those things you only know with the invasive procedures and I am pretty sure its a freak occurrence and not age related!

[Renee Del Ponte]

...

[AKMom]

Good Morning (8:53 here in Alaska)

LynnieC-- just thinking about you. Telling you not to worry is futile, if you are like most women, you are exhausted with worry. Sorry girl! Keep thinking positive thoughts.

Renee--I am sure having a baby 38+ is harder than when one is 20ish....I remember how I felt when I had my last child and was 30, I was a zombie with fatigue! I was a stay at home mom for a dacade, (HARDEST Job I've ever had!), I don’t know if I was tired because of my age or because, or that I had a family and never any rest to begin with. It sounds like you are making a concerted effort to get some rest-- a little one growing can and will suck the life out of you. Keep it up!---if you can.

Kelly 12 step program. Bawwhahaah that is funny! Hey we need someone to keep us all corralled. Not to mention your being nurse what a huge help you are have been and continue to be. You should be exhausted. 12 step, that is still making me laugh.

Kat

[AKMom]

Hi,

I don't know how to make this pic smaller. ...sorry but this is my DH and I last spring. Valdez, Alaska..

[Suzanne18]

Hi! I'm new to the group, but happy to have found you. I'm 41 and ending week 5 of my pregnancy. So far, so good, although I'm anxious about my first ultrasound on Monday. My RE implanted 5 Grade A embryos and the remaining 4 made it to blast and were frozen. (12 eggs retrieved/10 fertilized, 1 abnormally/of the remaining 9 Grade A embryos, 5 transferred on day 3 and 4 frozen on day 5). Just a little background - am happy to correspond online and wish you all the very best of luck and good health. Go, girls!

[lynniecat]

Hi Suzanne,

Great news on the pg! Congrats.


Renee,

Yes its hard and if the baby is seriously affected, I would have to do the unthinkable. I will not bring a baby into this world only to suffer. Its not fair. I just hope its not the case. We do not even know the details of what this piece of chromsome is. Its large though, so they think its not harmless.

I am waiting to hear back to see if I can get an ultrasound to see if the baby is doing ok right now. Is she the right length and does she have her various parts she should have at 14 weeks. I have a feeling they will say I have to wait.


I am off to get my blood tested to see if I have this piece of chromosome in me. Unlikely, but if I do, then we are ok...

DH is getting tested too!

[NY4thtry]

wow a lot has been happening on here.. as you all kow i have been staying away because of the dreaded.. well anyway

Lynie.. i cant believ what i am reading!!! i am going to say SOOO many prayers for you .. i dont know what else to say or do except that i feel it may be alright..

If you have questions you want answered a great place to post is in SIRM bords www.haveababy.com

the Drs respond and i think the las veags clinic may specialize in this >> hugs

[teachertam]

Hello Ladies,

Lynnie: I'm so sorry to that you have something else to deal with. It is just not fair. You are supposed to be able to enjoy your pregnancy, not worry all of the time.

Suzanne: Congrats on your pregnancy!

Renee: That is a great family photo. I should post a photo of my family, but I don't have a recent one.

Kat: That is a very nice photo you and DH. The scenery behind you looks breathtaking.

SueQiwi: Grow follies grow!!!!!!

We are off to Walt Disney World tomorrow. Hopefully, DS will be a good flyer.

Hello to Kelly, NY, Natasha and anyone else that I may have missed.

Take care all,
Tammy

[Liam'sMommy]

Hi Suzanne. Welcome and CONGRATS!!!!! So it looks like you are 16 dpo on you last beta. OMG it looks like you are having multiples for sure. I mean triples/quads. This is the chart from Betabase. It does not copy and paste right. Sorry, but you can go there yourself if you can't understand this.

http://www.betabase.info/showBasicChart ... pe=Triplet

Beta Scores for Successful* Triplet Pregnancies

Days Past Ovulation....................................................column 1
Median HCG Level.......................................................column 2
Lowest HCG Level Reported..........................................column 3
Highest HCG Level Reported.........................................column 4
Number of women reporting a number for this day.........column 5
10 43 2 243 10
11 59 2 173 34
12 78 4 348 59
13 190 10 486 107
14 262 23 1157 174
15 356 16 2010 216
16 537 16 2883 226[/
17 879 21 3193 217
18 1182 22 8060 193
19 1708 51 7998 166
20 2449 51 14500 143
21 3550 70 13287 114
22 5045 96 21538 97
23 7014 182 24302 82
24 9038 928 39314 67
25 12775 1288 39365 52
26 16174 2610 68000 42
27 20356 3019 60064 38
28 27776 4129 85215 34
29 36884 4129 85215 26
30 47106 6070 107564 21

Lynnie, thinking of you. Please update us when you find out ANYTHING. Are you still have your other health problems?

Kat, you guys are great looking too. You certainly don't look like a cougar. The scenery is breathtaking.

Sue, how are those follies doing? Do you usually have a lot more? If so maybe you could convert this to IUI to save money for another cycle.

Renee, how many boxes of mac and cheese have you eaten today? I am so happy you set things up for Rocco. What did you do for his B-day.

NY, thinking about you. Keep us posted. Sorry, i just don't know what to do.

I am glad you guys have posted pics. It is nice to have faces for names. I am way to inept to do it. I suck with computers.

Hello to everybody else.

[lynniecat]

Hi Guys,

I have been doing more reading....

So now I understand that what they found was what is called a marker chromosome...ie a mish mash of material that is not an actual direct piece of a chromosome.

When a marker is found in a cultured prep as mine was, the chances are 74 percent that the baby is not affected. So the odds are still on my side.

Apparently, if they can determine the origin of the marker chromosome -- like it is mostly derived from chrom 15 or from chrom 8, I will have a better estimate on my chances for a healthy baby. As far as I could tell, they did not know that information yet. It sounded like they may be able to tell me, but who knows. Sometimes, they can not figure it out.

Also if the material is mostly non-coding (heterochromatin) DNA vs coding (euchromatin) DNA, I am in better shape. That means if the extra DNA actual has the ability to make protein products vs basically doing nothing. Obviously if it does not really function, the chances of a normal baby go way up. Once again, they did not give me this information. They should be able to figure that out by the banding pattern (what the chromosomes look like...

So they information I need is

1. Which chromosome was this marker derived from...

2. Does the chromosome contain DNA that will turn into protein products or does it contain "filler" DNA.

3. Is this marker present in me or DH? Blood taken today for testing.


Once I know this (hopefully before the amnio) I will have more accurate odds.

The fact that it was found at such a low level makes me feel a strong need to do A LOT of testing in on the amnio. I have read cases where the amnio was clean because the extra material was only present at a low level in the baby, but it still had serious consequences for the little one.

I called the genetic counselor TWICE (once yesterday and once today) and no return call. I am pretty annoyed. She said to call anytime for more information or to just talk. Well that only works if she picks up the phone to answer it or call back!!

Thanks for reading!

[Suzanne18]

Lynnie... you sound a lot like me... I need to research, and research some more... then outline the details incl. what further information I need... you're going about it the correct way and as we all probably know, we need doctors' professional opinions/advice, but often times, we are more intimate with the details... a friend of mine is an MD, and he's the first to advise to review/keep ALL records/copies of bloodwork, other testing, etc. because there are cases where the patient uncovers details that are overlooked due to doctors' volume of patients... a great doctor is open to discussion, particularly if you've uncovered something.

you're in my prayers, as are the rest of the girls here.

Liam's Mommy... your posting made me laugh (and shiver)... I understand the table completely!... I've also read that the ranges for singletons/multiples do overlap, so perhaps it's just one... three or more scares me... additionally, I don't want to be on television - let's leave that for octumom... thanks for the info... I may have some answers after Monday's ultrasound.

teacher... thank you for your kind welcome!

[Liam'sMommy]

Suzanne, i spaced and misread your dates. I thought you were 16dpo/16 days post ER but you are 16dpt. So you are only 19 days post ovulation. So i don't think its HOM. Sorry for the scare. You could still have twins though. I can't wait for the US. Keep us posted.

Lynnie, you have been a busy little bee. Good for you. I want to kick the geneticist's ass. That is so wrong to drop that kind of news on somebody then not be available to answer questions. That is poor form!! Praying for you and your little one.

Hello everybody else

[Suzanne18]

Liam's Mommy... no, you were right the first time - I'm just a moron... I updated my profile (below)... it was supposed to say ER, not ET... too many dates and acronyms!... guess it doesn't matter how many I have, I can't count anyway lol