Comprehensive Chromosome Screening

beefjerky · Post by **beefjerky** » Mon Jan 26, 2009 5:11 pm

Does anyone know much about this? They are doing it at CCRM, but I think still as trials. The success rate of IVF using this method was 80%. Can any of their patients do this? Does anyone know how expensive it is?

beefjerky · Post by **beefjerky** » Mon Jan 26, 2009 6:04 pm

I talked to CCRM and got the answer. Yes anyone can add this service for $5000 extra per cycle.

NY4thtry · Post by **NY4thtry** » Mon Jan 26, 2009 6:10 pm

i think what you mean is CGH.. which has to be done wth a frozen cycle.. SIRM pioneered this and there are papaers you can look at on their website

Liam'sMommy · Post by **Liam'sMommy** » Tue Jan 27, 2009 9:07 pm

NY, is correct. SIRM started it and now only SIRM and CCRM do it. The results take awhile so you must do FET. I am doing it through SIRM. I am doing three retrieval/cgh/banking cycles before i do an FETs. That is if i have any normal embryos left.

wishing4baby · Post by **wishing4baby** » Wed Jan 28, 2009 7:42 pm

I will be doing the same thing, but not until April when my clinic will begin offering the service. I believe it is able to test all 23 chromosomes instead of just the 12 that regular PGD tests.

I will have my retrieval in Feb/Mar, they will freeze the embryos and then send them for testing in April. I too hope we get a few normal.

I am interested in hearing anyone's experience who has already had this done.

Liam'sMommy · Post by **Liam'sMommy** » Mon Feb 16, 2009 3:51 pm

Go to the Colorado thread on IVF Connections. There is a big list they have going of recent cyclers/stats at CCRM. The stats will blow you away. I can't find a good list of SIRM patients even though they have done it quit a bit longer.

I have a question, is your clinic doing the biopsy on day 3 or day 5?

wishing4baby · Post by **wishing4baby** » Tue Feb 17, 2009 12:58 am

I believe my clinic will do the biopsy on day 3. My doctor will freeze all right after fertilization and then when we are ready to send for biopsy in April they will unfreeze and let them go to day 3.

My doctor told me that they can't do the CGH testing on day 5 embryos because it takes too long to get the results and it is risky to refreeze after the initial freeze took place after cell division.

I only know this becuase we have 5 frozen blasts that my RE inquired about using for CGH. The lab they use said it wouldn't work with day 5 embryos.

How are you working it? I think you said you are banking the embryos over 3 cycles. Are you having all tested at the same time or 3 different CGH cycles?

lynniecat · Post by **lynniecat** » Tue Feb 17, 2009 1:42 am

You know CCRM was pushing this on me even though their genetic counselor pointed out that since I always put back all my embryos it would be silly. I can always do CVS and Amnio later (which insurance covers).

Now, I have a slightly different view. My CVS came back inconclusive and now I wait on an amnio. In my particular case, the CGH might not have helped...but....imagine this scenario...

Say you are someone who would end a pg if there was a severe defect, like trisomy 18 or turner syndrome. Would it not be much better to not put back the embryo to begin with? So I now think testing is a great idea as it avoids that kind of awful decision and moral stress.

The only reason not to do is :

a. You can not afford it.
b. You worry that embryos that would have made it in the uterus will not make it through the additional culture and freeze thaw.

If I were to do IVF again, I think I would pay the money for CGH...

Funny how life experiences can change your thoughts and opinions on things. I always thought doing CGH when you know you are going to only have 3 or 4 embyros anyway was a waste of money because you have amnio and CVS to check...but finding out that information at 14 weeks is really NOT the same as finding it out before you even try to get pg with that particular embryo...

Kind of a tangent here, but wanted to share my eye opening experience..

41andscaredsilly · Post by **41andscaredsilly** » Tue Feb 17, 2009 2:18 am

ladies, please forgive me if my information is a bit unclear but can anyone explain why this is preferable when an amnio can test for all the same without having to freeze the embryos?

I understand the moral/ethical issue about when the amnio can be done the embryo is no longer a mass of cells but a baby. It is my understanding that testing before risks the embryo much worse than an amnio does and on this point I'm very clear because we specifically asked our doctor. He said the only time he recommends that is IF and WHEN there is a strong history of problems because it weakens the embryos so much.

As I sit waiting for Friday to find out results I'm struggling with the best case scenario of all four embryos sticking. Selective reduction prior to 23 weeks as is the law in our state, with the advice of both our doctor and a perinatologist, sounded ok at the beginning. Now I'm not sure.

I'm not trying to be confrontational here, but as far as avoiding the issue altogether -- well that seems fine on paper but you and your partner are going to know that embryo is still out there, unless you discard it. That begs the question if you discard it in the end, how's that different than selective reduction based upon the results of an amnio?

bdantonio · Post by **bdantonio** » Tue Feb 17, 2009 2:07 pm

im unclear now.. Are you saying if all four took you are doing selective reduction or u have to

41andscaredsilly · Post by **41andscaredsilly** » Tue Feb 17, 2009 2:40 pm

I'm saying I don't know what I'd do. But for me personally, I can't see how testing beforehand and deciding to discard is any different than reducing based upon an amnio which detects the same abnormalities.

The day of transfer, after hearing the doctor's assessment, I asked our doctor what he would do if his wife were the one sitting in the hospital gown. He said "transfer all four" to which my husband and I said almost in unison, "I don't wanna be the next octuplet mom" He smiled and said "you won't."

However, when we were first going through the process we sat in his office and discussed the testing of the embryos before implantation and he strongly advised against it unless we had a history of serious genetic problems because it weakens the embryos. I got very concerned when he wanted to implant three blasts because the thought of 3 babies scared me. He went on to give the whole "at your age it would be entirely unlikely all four would make it" and then went through the whole selective reduction conversation.

It seemed so far away at that time, but not so much now.

bdantonio · Post by **bdantonio** » Tue Feb 17, 2009 2:43 pm

okay i understand now.. My first dd all my tests came back she had downs.. 1st trimester screenind, triple screes and level 2 u/s. We refused an amnio as u can see im high rish for m/c and i would not take that chance. I am only 26 and 22 when i had her however i was 19 when i found out i was in perimenauapuse so my chances were high of not having children. I hear of some of the high egg production on here mine was never high and i was 20 when i started.

41andscaredsilly · Post by **41andscaredsilly** » Tue Feb 17, 2009 2:51 pm

Ok now I'm unclear -- did you carry your daughter to term or did you miscarry. If you miscarried I'm so sorry for your loss.

I have very good friends who had IVF years ago and after several cycles were blessed with a set of twin girls. One of the girls has downs the other does not. Both children seem happy and well adjusted.

This is where I hope the oh so smart embryos take care of the situation without my intervention! Is that mostly what happens the strong ones survive and the others just go away?

bdantonio · Post by **bdantonio** » Tue Feb 17, 2009 3:21 pm

i had her at 39 weeks and she was perfect.. nothing wrong every test was wrong.. i so dont trust the tests...

41andscaredsilly · Post by **41andscaredsilly** » Tue Feb 17, 2009 3:25 pm

YAY for you and for her!

Do you mind sharing how many you had implanted?

Comprehensive Chromosome Screening

Comprehensive Chromosome Screening

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