AFM- Got call from RE today regarding FET. We are a go for this Sunday, Easter! That means beta 4/21- DH's birthday!! I had originally thawed 6 day 1 embryos, and 5 made it. Of those, today being their day 3, they all look good at 3 above average, and 2 at excellent. So they felt comfortable letting them attempt to grow to blasts for our transfer on Sunday. Hopefully we won't lose many!The embryologist, which I love because he takes the time to answer all my questions, said we will be giving me Easter Eggs! How cute
My big problem now, is the dreaded question of how many to transfer. I really want to improve my odds of getting prego, and since my fresh cycle failed, I am leaning towards 2 Easter eggs. The other side is I really don't want multiples, so then I lean towards 1. I hate this decision. I want a crystal ball to tell me what the future holds- Yeah Right!
BTW my RE gives pregnancy a 40% chance with 1 blast & 45-50% chance with two. Seems really low to me. I am 36 and have endometriosis. Any advise you guys have on how you decided, or what numbers you were given for percentages would be very helpful. Aims, Cynthia, Latinosunshine & anyone doing PIO, even if DH does it (or Mom 
) here is a good article I found:The injection is much easier if you warm the progesterone beforehand. The oil thins out when heated and needs less effort to inject and bruises less. You can do this by holding the bottle of progesterone, or a syringe with the proper amount of progesterone in it, in your hand for a few minutes prior to the shot.
Progesterone is made in peanut and sesame oil (in the US anyway, not sure about overseas). If one form is particularly bothering you (lumps, rash, etc.) try switching to the other kind of oil. You may have a slight allergy to the original oil.
Progesterone in sesame oil is a tiny bit less viscous than progesterone in peanut oil, so it goes through small needles a little better.
Try not icing the area beforehand, if you can stand it. Chilling the muscle first may make it harder for the progesterone to dissipate.
Moist heat on the area may help dissipate the progesterone and make the area less painful. (Microwaveable heating pads are perfect for this!)
Massaging the area after the shot helps the progesterone dissipate.
If you have lumps forming, try to make sure the shot doesn't go right into one. If it does, it makes the shot extra painful.
Most clinics recommend that you do progesterone shots in larger needles because the oil is so much thicker than the other medications. You can use smaller needles (25 to 27 needles gauge work fine). The injection will take longer, but it may help reduce the pain and soreness from the shot. (It will not affect whether the progesterone itself is painful or forms lumps.)
Remember that progesterone often brings on pregnancy-like symptoms, and also makes your cycle longer. So, if you're on progesterone and have breast tenderness, etc., you arenÕt necessarily pregnant and you will need to have a test to know for sure.
Remember that you can still be pregnant even if you seem to have started your period, so be sure to go for your blood pregnancy test before stopping progesterone support.
Here's my PIO experience with self injections (have only done it 3 times now) for what it's worth. I originally did my own HCG shot as well for my fresh cycle, and like Cynthia, it took me a while to get the courage to do it. This time, I literally just went for it, since last time the build up was the worst part. Take it from me, just go for it. It's really not that bad, I just started doing 2cc last night, and that was more sore, but I'd rather do it myself than have someone else do it (probably the control freak in me). I don't use a mirror, but either way is fine. I do heat the vial in my beany while I prepare stuff. I like to have everything laid out including my bandaid. I think I may start heating my skin first also, like one of the girls here suggested and the article as well. That will probably numb the skin a little and also keep the PIO nice and thin. I will try that tonight. My clinic said I didn't have to pull back to see if there is any blood in syringe, but I always do, I was trained to as an RN and I don't want to give my self PIO intravenously. Also, after hearing Cynthia's accounts of it being a lot more painful, I have decided it's better to pull out and find a new site if I do get blood return.
Well, aims if you have more questions ask away. We had a bit of a discussion earlier about doing the left side (for right handers) and I have found it to not be a problem, you just have to twist more.
Good luck with it!
Melanie
I'm starting to get scared about those "PIO" shots. At least I think my progesterone is pills. Not sure if is really better but at least. 
Stop double thinking it. I would say your biggest worry from here is MULTIPLES 
