Any advise Ghost?

[LMV]

Hi Ghost, first, I wanted to say thanks so much for doing what you do, you're a great help!

Our first IVF we got 17 eggs 2 put back and 5 frozen. I got BFP but m/c @ 5 weeks. We did a FET only one made it to transfer. Again BFP m/c again.
This fresh one they got 15. 13 out of the 15 fertilized, but then at transfer time we had 2 really strong blasts put back, but none of the others made it to freeze. Is this a sign that something could be wrong with egg quality?
Both DH and I had chromosone testing on ourselves done, those tests came back fine. My Dr does PGD but says it can cause a lot of stress on the embryo. We are currently in our 2ww. Only 6 more days til test time. I was just wondering what your thoughts would be on this.
Any help is appreciated!
Thanks!!!
Lesley

[Ghost]

Hi Ghost, first, I wanted to say thanks so much for doing what you do, you're a great help!

Our first IVF we got 17 eggs 2 put back and 5 frozen. I got BFP but m/c @ 5 weeks. We did a FET only one made it to transfer. Again BFP m/c again.
This fresh one they got 15. 13 out of the 15 fertilized, but then at transfer time we had 2 really strong blasts put back, but none of the others made it to freeze. Is this a sign that something could be wrong with egg quality?
Both DH and I had chromosone testing on ourselves done, those tests came back fine. My Dr does PGD but says it can cause a lot of stress on the embryo. We are currently in our 2ww. Only 6 more days til test time. I was just wondering what your thoughts would be on this.
Any help is appreciated!
Thanks!!!
Lesley

Some clinics have used PGD to try to improve IVF outcomes. This has been shown to not work in the general population. If anything, it caused more harm than benefit, reducing implantation rates through the slight damage to the embryos. This explains the recent push for non-invasive techniques to try to determine embryo viability.

However, there might be a sub-population in which PGD is beneficial for improving success rates. These would generally be those rare, few women who produce large cohorts of embryos, many of which make it to the blastocyst stage and appear normal, but are mostly abnormal. PGD can work to cull through the many to find the few good ones to transfer.

Again, that kind of patient is the rare exception.

However, women who produce only the number appropriate to transfer (like 1 or 2 blastocysts) would see no benefit. If there are so few, there is no mystery to solve regarding in which embryos to transfer.

Did you test the products of conception? An SAB does not automatically indicate a genetic defect. Embryos that pass complete chromosome analysis can still have an SAB, and sometimes the analysis of the abortus comes back genetically normal.

Did they get to the point of doing an ultrasound? What did they see? Sometimes a genetically good embryo has a lousy ICM, and although the sac (trophectoderm) implants and develops, there is no baby inside. These are called "anembryonic gestations" or sometimes a "blighted ovum".

Of course, PGD is good for screening out genetic disease, like Down syndrome, cystic fibrosis and such. It certainly has an important role.

[LMV]

Thanks so much for your reply Ghost. I'm sorry this is so late, things are not going well again and I've been to down to get back on here. We did the transfer on 6/7 and I started bleeding on 6/14. It was mostly brown, but some very dark red too. We did our pg test on the 17th it was again BFP the # was 55.5. I let them know I had been bleeding since Sunday and my nurse sd that was a concern with my history. I went back in yesterday 18th and it had gone up to 62. So, once again not a viable pregnancy. We are at our witts end with. DH sperm has been tested. We've both had chromosone testing. My uterus always seem to look good. We have to wait for our #'s to go to 0 before a consulatation with the Dr. I just want answers now.
What sorts of non-vasive tests should we ask about?
They only got to the point of u/s once that was the first time we m/c and it was the blighted ovum. The second time and now this time did not make it to u/s.
I'm not sure what you mean by "Did you test the products of conception?"
Or what a SAB is.
I'm trying to get a list of questions to ask our Dr when we do meet with him. I just want to look at any possible solution. Is the eggs? sperm? uterus? embryos? We are just so frustrated! Any feedback you could give would be appreciated!
Thanks
Lesley

[Ghost]

Thanks so much for your reply Ghost. I'm sorry this is so late, things are not going well again and I've been to down to get back on here. We did the transfer on 6/7 and I started bleeding on 6/14. It was mostly brown, but some very dark red too. We did our pg test on the 17th it was again BFP the # was 55.5. I let them know I had been bleeding since Sunday and my nurse sd that was a concern with my history. I went back in yesterday 18th and it had gone up to 62. So, once again not a viable pregnancy. We are at our witts end with. DH sperm has been tested. We've both had chromosone testing. My uterus always seem to look good. We have to wait for our #'s to go to 0 before a consulatation with the Dr. I just want answers now.
What sorts of non-vasive tests should we ask about?
They only got to the point of u/s once that was the first time we m/c and it was the blighted ovum. The second time and now this time did not make it to u/s.
I'm not sure what you mean by "Did you test the products of conception?"
Or what a SAB is.
I'm trying to get a list of questions to ask our Dr when we do meet with him. I just want to look at any possible solution. Is the eggs? sperm? uterus? embryos? We are just so frustrated! Any feedback you could give would be appreciated!
Thanks
Lesley

I'm sorry to hear this.

I'm also sorry my previous post was not clear. SAB is spontaneous abortion, basically a miscarriage. The "products of conception" is a euphemism for the expelled fetus after the SAB. These are sometimes genetically tested to determine why it occurred.

The non-invasive tests are not ready for prime time. And I doubt they would determine a cause of SAB. I only mentioned them because they are a current research area.

Perhaps you are a candidate for PGD. Not to improve the chance of implantation, but to solve this mystery of what's going on with these losses. Yes, PGD does harm the embryos a little.