Please can anybody help/advise??

Discussion group for all topics related to infertility including preparation for pregnancy, causes, investigation and treatment of infertility.
Nick
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Joined: Mon Jan 13, 2003 1:59 pm

Please can anybody help/advise??

Post by Nick »

Can anybody help out there? I am a bit puzzled and would like to do some crude research.

When I started IVF I managed to produce 8 eggs on Puregon. Thereafter I have been with my NHS hospital, and they supply only Gonal F. Since then (FSH 8.3) I have produced fewer eggs - although managed a pregnancy - all be it up to 8 weeks. 2nd go - my cycle was abandoned, nothing in follicles. 3rd go - four eggs (POSITIVE though) and 4th attempt .....the grand total of two eggs!!! I am waiting to find out if either have fertilised - if at all.

I am wondering if I or anyone else have noticed if they respond better to one type of FSH. or the other?

This is crude research, but I would like to know if there could be a difference. I have had IVF every three or four months - so I have aged only a 17 months since the first treatment.

I know it only takes one - so keeping every bone in body crossed - but not hopeful.

Good luck to anyone who is on this flippin' merry-go-round.
Nicky :?
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Dagny
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Post by Dagny »

Hi Nicky

Fingers crossed for your 2 eggs. It does just take one but I can understand your concern.

I have had 3 treatments and each time have used Puregon and got 12, 12 and 15 eggs. I have a tendancy to hyperstimulate as well. I can't really answer your question as I have always used the same FSH. Perhaps you should have a longer break between treatments to let your ovaries get back to normal.

But it won't matter because this one will be a success!!!

Good luck

Love Dagny xkx
Me 38 DH 40
1st 2nd & 4th IVF/ICSI -ve
3rd +ve DD Katelyn born @ 24wks & sadly died
5th +ve m/c 9wks
6th +ve Twins Sadly DD Leah stillborn @20wks and DS Kieran born @22wks but sadly died too
7th +ve - DD Chloë Mae born @38wks our precious miracle
Nick
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Posts: 57
Joined: Mon Jan 13, 2003 1:59 pm

Post by Nick »

Dagny,

It's not good news (feel more gutted than when I had my m/c) The two embryos, one is too immature to fertilise and the other is mature - but 24 hours later still hasn't fertilised. They still want to transfer on Wednesday. I'm trying to do everything to make this work and feel the end of the road staring at me.x
Dagny
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Location: Redhill, Surrey

Post by Dagny »

Oh Nick :(

I am sorry. What do they say about the odds of the mature one fertilising after this time? If they still want to go ahead with ET on Wednesday they must be confident that something will happen. You poor thing, you must feel so low. But try to be positive. Stranger things have happened.

Thinking of you and fingers crossed.

Let me know how things progress.

Love Dagny xkx
Me 38 DH 40
1st 2nd & 4th IVF/ICSI -ve
3rd +ve DD Katelyn born @ 24wks & sadly died
5th +ve m/c 9wks
6th +ve Twins Sadly DD Leah stillborn @20wks and DS Kieran born @22wks but sadly died too
7th +ve - DD Chloë Mae born @38wks our precious miracle
Tracey S
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Post by Tracey S »

Nick

So sorry to hear the news - I am not much help I am afraid as was on Gonal F and over stimulate and produced 41 eggs last time at 36 years old! WEre you on long or short protocol as this might have made a difference?
Fingers crossed this will be the golden one and continue that way.
Good luck
Love
Tracey
xxx
ttc 9 years. 38 yrs old, dh 8 hrs younger!First IVF in Aug 2002 and had ectopic.2nd IVF neg.3rd FET and negative.4th FET and positive but sadly lost our little boy at 20 weeks.5th FET and Alice Isobel and Emily Charlotte born 5th Aug 2004!
KarenSmiff
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Location: Central England

Post by KarenSmiff »

Hiya Nick

I am a poor responder like you. 1st ICSI abandoned, 2 follies on long protocol. Then 2nd go Short protocol - 3 eggs, 1 embie -neg.
3rd go shortie, 4 eggs, 3 embies, 2 put back - neg, 4th go 5 eggs best so far (after 7 month break), was devasted when i called them the next day and the told me only one out of the five was mature. Cried and cried. Well it fertilised to 2 cell. I was adamant it wasnt going to happen, and it did. I got a BFP. But sadly ended in miscarriage at 9 weeks only last week.

What bugs me is that my doctor (& i am private each time) , wont change my dosage or drugs??? 5 amps menopur a day, short protocol for 3 cycles. But i suppose they know best????? Isnt gonal F stronger???

Good luck
preying that you make a little embie


Lots a love
karenx


(My FSH was 11 then 9, and I am 31...ready for the knackers yard i fink?)
sharoninsomerset
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Post by sharoninsomerset »

Hi Nick,

I too am a poor responder - I am having EC tomorrow 5th attempt, but last one cancelled as only one decent follie. Well I am on Menapur 4 vials each time which is the most they will give me. They have offered Gonal-F but have said that it is only 'safer' as synthetic rather than Menapur and wouldn't make much difference to response. You either respond well or not I think - as I have been consistant with all 5 goes - 3,3,3 abandoned and hoping tomorrow for 4 or even 5.

Hoping that you get your one embrie tomorrow.
Sx
me 38 DH 47 - TTC - 3.5 years - tubal infertility
4 failed IVF cycles - 1 abandoned
Found to have raised FSH when going for 5th cycle
Now looking at adoption
Let the new adventure start!
Sx
Nick
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Posts: 57
Joined: Mon Jan 13, 2003 1:59 pm

Post by Nick »

Thanks for all your sympathetic messages. The whole thing is a real mystery - on Puregon 8 eggs and subsequent attempts all within a year fours and two eggs.

Well, nature managed to do its trick. Eventually the one and only egg fertilised, 24 hours later (ah -hum). I was waiting the next day to find out if we had to trot in for ET, and if it managed to cleave.

Next day, the embryologist was ecstatic and said that it had caught up and was a 4 cell! When we arrived it was busy cleaving. Lots of fragmentation though.

So girls, clutching at straws again. No shouldn't say that, I, like the blackbird and wren in the garden am sitting on a late developing, feisty embryo.

I mentioned about Puregon and Gonal F to my consultant, and he had remarked how women had performed better with Puregon - and injected intramuscularly.....I also suggested that I had not been monitored properly. One scan - then oopps you must go in for EC......no blood tests either.

I reckon if this were a wholly male problem, infertility, more research would have been done. There, there, no need to be cynical now. :?

Karen, sorry too to hear of your amazing story as I m/c at 8 weeks. The only solace is that we managed implantation. Have you thought of changing your clinic, particularly if they have not come up with anything more suitable and just repeating the same dosages?

Tracey S. Glad that you are bloomin' and hanging in there, or hanging low, should I say. Hope you survive a sticky summer and keeping your feet up 8) 8) 8)

Dagny, Thanks too for your message. I don't know about feeling low, it is all relative, and you are very close in all our hearts on this board. I am take a longer break between tmts but will 39 in July, and will be moving to Surrey, so I have been making the most of a) NHS attempt which failed and b) NHS attempt received following that .... it all had to be done in close succession. But I take your point, if only to rebuild normality into our lives.
Nick
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Posts: 57
Joined: Mon Jan 13, 2003 1:59 pm

Post by Nick »

Thanks for all your sympathetic messages. The whole thing is a real mystery - on Puregon 8 eggs and subsequent attempts all within a year fours and two eggs.

Well, nature managed to do its trick. Eventually the one and only egg fertilised, 24 hours later (ah -hum). I was waiting the next day to find out if we had to trot in for ET, and if it managed to cleave.

Next day, the embryologist was ecstatic and said that it had caught up and was a 4 cell! When we arrived it was busy cleaving. Lots of fragmentation though.

So girls, clutching at straws again. No shouldn't say that, I, like the blackbird and wren in the garden am sitting on a late developing, feisty embryo.

I mentioned about Puregon and Gonal F to my consultant, and he had remarked how women had performed better with Puregon - and injected intramuscularly.....I also suggested that I had not been monitored properly. One scan - then oopps you must go in for EC......no blood tests either.

I reckon if this were a wholly male problem, infertility, more research would have been done. There, there, no need to be cynical now. :?

Karen, sorry too to hear of your amazing story as I m/c at 8 weeks. The only solace is that we managed implantation. Have you thought of changing your clinic, particularly if they have not come up with anything more suitable and just repeating the same dosages?

Tracey S. Glad that you are bloomin' and hanging in there, or hanging low, should I say. Hope you survive a sticky summer and keeping your feet up 8) 8) 8)

Dagny, Thanks too for your message. I don't know about feeling low, it is all relative, and you are very close in all our hearts on this board. I am take a longer break between tmts but will 39 in July, and will be moving to Surrey, so I have been making the most of a) NHS attempt which failed and b) NHS attempt received following that .... it all had to be done in close succession. But I take your point, if only to rebuild normality into our lives.
Zed2003
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Post by Zed2003 »

I just wanted to say that mother nature does what she wants, and I'm so glad you got a fertilised egg. Keep positive - on my last IVF, I only got 2 eggs (about normal for me). One fertilised after 24hrs, the other didn't. When we went in for egg transfer the next day, the one that had fertilised had not split and done nothing, the one that had done nothing was ovbiously a late starter and lazy and was a 4 cell by the time we got to the hospital! They put both back anyway, and after a rocky ride, we now have Sam who is 15 weeks today! (and right enough - boy does he love his sleep, the lazy tike!)

Relax, take it easy and I wish you all the best!
Zoe
Nick
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Post by Nick »

Dear Zoe,

Just had a quick peep to look at the board, and was so glad to hear of your comforting story...in fact, way back, when I had m/c I realised that you too had been in the same situation. M/C then successful.??? It was precisely your story and perhaps, one other girls, that gave us faith to crack on again!!!

Amazing to hear from you again....

Even weirder, my border terrier, has come out in sympathy - she has a phantom pregnancy - little mucus from her teats. The last session she was exactly the same - loafed about on our bed and sofa, the most exercise moving from one duvet to the next. How bizarre?! The day I miscarried - she was almost run over.

I am not into psychic things, tarot etc... but oo er... all bit of a coincidence.

Thanks again for your message, it will at least help me get through the 2ww. and lots of cuddles to your little Sam - well done :wink:
Zed2003
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Post by Zed2003 »

Hi Nick,

Glad I could be of some use...
Yip to the m/c query. 1st attempt, no +, 2nd go, + but ended in m/c, 3rd go (and paid by NHS!!) resulted in our pride and joy...

As for your dog....big time weird! This time you'll be wanting her to get big and fat then!!! LOL. OMG, if she has 6 puppies, what will that say for you :lol: :shock: (sorry, trying to lighten the situation!)

Take care and try and relax on 2ww. Keep in touch...

Zoe and Sam (who loved his cuddles!!)
Dagny
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Post by Dagny »

Hi Nick

How are you feeling today? Positive thoughts I hope???

I am the opposite with you for monitoring. my lot get me in everyday once I start stimms for bloods and scans. It's a real pain as it is a 1 and a half hour round trip to the hospital but I would rather that than OHSS!! I can't believe how little monitoring you have had, I would complain if I were you.

Keep your chin up and be positive. Thinking of you.

Love Dagny xkx
Me 38 DH 40
1st 2nd & 4th IVF/ICSI -ve
3rd +ve DD Katelyn born @ 24wks & sadly died
5th +ve m/c 9wks
6th +ve Twins Sadly DD Leah stillborn @20wks and DS Kieran born @22wks but sadly died too
7th +ve - DD Chloë Mae born @38wks our precious miracle
Nick
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Posts: 57
Joined: Mon Jan 13, 2003 1:59 pm

Post by Nick »

Dagny,

Thanks for your comments. I was keen to complain. I in fact stopped the cheque clearing, whilst we waited for the egg to fertilise. Very bitter and angry.

However, in the rules once fertilisation has taken place - clients must cough up.

As for complaining. Yes, we have every reason to. I spoke to the HFEA and they red taped us - "not our problem - do it through the hospital's complaints procedure".

But as things are I am suspicious that if I were to complain - with every reason to - I will get stressed and not give my body the best chance. We have been successful with the hospital, when I m'c about 8 weeks before you sadly lost your little one. So you can see I am in an awkward position. They admit the EC/ET are always on Mon Wed Fri !!! No w/e work... so I expect the cost of 1800 reflects those slimline procedures.

Now, more importantly, I hope YOU are going to be positive about your June cycling. You were deeply unfortunate to have suffered so, when I read your news I was physically very shocked - almost numb. All comfort I can give you is try and think on the positive side - to get a pregnancy at all is a good thing. Keep resting, and try and put the potential worries behind you. (I was numb with fear when I was pregnant, convinced I would lose it...so I know now, that simply a positive is just the start of this merry dance).

Take care, Nickyx
Dagny
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Post by Dagny »

Hi Nicky

Thanks for your kind words. It is such a comfort to know so many of you are behind me and will help me. I have just had some very bad news from a friend who is PG with twins and I feel numb and shocked, so all my emotions are resurfacing again.

You are right, getting stressed about complaining will not do you any good so just let it be for now but I don't think I would let it lie. The HEFA always seem to 'pass the buck'!

Take care

Love Dagny xkx
Me 38 DH 40
1st 2nd & 4th IVF/ICSI -ve
3rd +ve DD Katelyn born @ 24wks & sadly died
5th +ve m/c 9wks
6th +ve Twins Sadly DD Leah stillborn @20wks and DS Kieran born @22wks but sadly died too
7th +ve - DD Chloë Mae born @38wks our precious miracle
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