The Over 40 Crowd

Discussion group for all topics related to infertility including preparation for pregnancy, causes, investigation and treatment of infertility.
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taylorjools
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Posts: 1341
Joined: Thu Mar 03, 2005 4:54 pm
Location: continental Europe

Post by taylorjools »

Hi girls, sorry another long post....just booked our flights so I am a bit hyper :shock: :shock: :shock: :shock: weather in Kiev jolly chilly...but we have 10 days so looking forward to the break.

Deb - great to hear from you, mega hugs, glad to hear you are planning and enjoying dh and dd as you wanted to enjoy them, {{{{{{ :) }}}}}}

Lara - any time you need help just let me know - also email OK??? It's hard to know what to do, but your heart will tell you what's most important.

Amfy-Good luck on your 2ww, and make sure you move around a lot at work - need to keep the old blood flowing you know :wink:

Randa - oh pooh hello af - well miracles can't happen every day can they?? although you deserve one. We should invent a waiting to cycle Advent Calendar ----and a 2ww advent calendar... now there's a business idea 8) I might just get my artistic brain round that on my 2ww :wink:

jen - keep up the PMA sweetie and don't let them waer you down. You need mega strop ammunition you call me and we'll send the boyz round 8) :twisted: 8) :twisted: 8) :wink:

actually amfy (+lara), something like that worked for us, although I didn't do it formally..here's how it went :
After the m/c I didn't want to wait 3 months - was told any way by Spanish clinic couln't treat my for 4 months cos of Summer hols sooooo that made me decide to research Kiev as an option as there we could afford more goes and their succes rates (LBR) were just as good as Spain. They also said wait 3 months soooooo I decided to use the time constructively:

1. we had m/c so I said no more tries until all possibilities tested
2. Hashimoto's immune thyroiditis diagnosed me- linked to m/c and NK cells so needed tmt took 3months to diagnose and stabilise anyway
3. Dh sperm tested by sperm guru as we had v.low fertilisation rates even with young egg donor - found <2% normal sperm aaaaaaggggghhh
4. Were recommended TESE so we went for it had TESE here in Germany and same rigourous guru tests - sperm normal (cost us €1500 but I decided it was worth it)

So, I said, then we will:
1. Use TESE samples
2. Do PGScreening
3. Do major Immune monitoring / tmt

well, Kiev said, with normal TESE why did we want to do PGS since the donor is 23 and healthy, it would have cost $1000, AND meant freezing the embryos while waiting for the results :shock: risk of thaw failure etc :shock: ummmmmmm. So I thought bugger that we'll go back to Spain thenmaybe they will be prepared to do it. Then I thought yeh but then we can only afford 2 goes, wheras with Kiev we can do 5 goes if we want....so Kiev won in the end without PGS. OK it's easier for us as our donor is young but maybe that helps??

Immune stuff - well now the Hashi do dooos is being treated with thryroid hormone, there is a good chance that I'll be Ok just a slight risk of immune issues (NK cells etc). Our Germany Uni clinic said Nk cells <29% is fine (I am 15%) and Prof Beer says 15% is the danger zone...again we decided to be practical - we are going to get one screen done if I make it to 6 weeks and take it from there. Otherwise I would have been flying in meds from the UK / States and getting my gynae to treat me wihout proper monitoring. At some point you do have to trust to luck, God and fate and just jump in.

I don't know if that helps, but I thought perhaps as our siutuation is so complex, the way we tried to simplify things and take it a step at a time might be of use. I too am absolutely terrifies of another m/c. I am sure it will feel like a time bomb if I do get pg, but I am going to try and take it on day at a time... and get counselling to boot :wink:

Oh - another thought - I know at least 2 women who decided to go for donor eggs to increase the chance of succeeding (I didn't have choice, mine are no more as they say), again, priority for them was pg and baby rather than necessarily own genes - very hard decision to make - very hard, but it does have it's advantages.

oh blimey I do ramble - sorry if I've been too opinionated, it is just my thoughts on the subject, hope it helps.

Love and hugs to all of us wonderful wise womb women

bigJ 8)
POF+autoimmune+dh antibodies,5.05 DIVF IM M/c 7.5 wks, DIVF+TESE at ISIDA - son 08/06
FET ISIDA: 12.07.07 m/c 8 wks b.ovum, 17 Dec 2007- BFP triplets OMG!!!
[img]http://tickers.TickerFactory.com/ezt/d/1;20726;0/st/20080905/dt/6/k/7529/preg.png[/img]
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AMck
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Posts: 1401
Joined: Tue Oct 25, 2005 3:26 pm
Location: Surrey

Post by AMck »

Hi all, have been away for the weekend (wicked hen party!) and have just been reading all the messages. Wow , so much going on.

My little cyst drain seems very teenie tiny compared to a lot of other things happening, but I'll update me anyway.

Kat - Fresh/donor cycle, hpt +ve!, blood test Tues 8th Nov
Nuala - fresh cycle, late Oct.
BigJ - TESE/donor egg cycle in Kiev, EC set for 23-24 Nov
Caroline - November FET postponed
Amfy - 2ww - test 25th November
Anna - cyst drain on 18th Nov, then start stimming
JackieT - start downregging 2/11 for FET
Heather - FET November sometime
Randa - Natural BDing until Jan, then first full IVF cycle
Lara - choosing tmt (IVF vs GIFT)

I had a scan this morning and it showed that my cyst was still there so am booked in on Friday to have it aspirated. My nurse said it was just the same as having an EC so not to worry.She then blushed slightly as I reminded her that we had never even got to EC stage!
Anyway will start stimming on same day as drain....another little step forward through this minefield. Any advice?

Hello and good luck to all. PMA PMA PMA

Anna
AMck
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Joined: Tue Oct 25, 2005 3:26 pm
Location: Surrey

Post by AMck »

Hi all, have been away for the weekend (wicked hen party!) and have just been reading all the messages. Wow , so much going on.

My little cyst drain seems very teenie tiny compared to a lot of other things happening, but I'll update me anyway.

Kat - Fresh/donor cycle, hpt +ve!, blood test Tues 8th Nov
Nuala - fresh cycle, late Oct.
BigJ - TESE/donor egg cycle in Kiev, EC set for 23-24 Nov
Caroline - November FET postponed
Amfy - 2ww - test 25th November
Anna - cyst drain on 18th Nov, then start stimming
JackieT - start downregging 2/11 for FET
Heather - FET November sometime
Randa - Natural BDing until Jan, then first full IVF cycle
Lara - choosing tmt (IVF vs GIFT)

I had a scan this morning and it showed that my cyst was still there so am booked in on Friday to have it aspirated. My nurse said it was just the same as having an EC so not to worry.She then blushed slightly as I reminded her that we had never even got to EC stage!
Anyway will start stimming on same day as drain....another little step forward through this minefield. Any advice?

Good luck to all. PMA PMA PMA

Anna
lara
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Posts: 104
Joined: Sat Nov 05, 2005 10:32 am
Location: London

Post by lara »

:o Hi all,

Thanks Jules for your detailed history - how fascinating, and the way you methodically worked through each problem - very admirable and pragmatic.

Amfy - cool, I think I'll try it, and if I get a baby that runs on diesel and has leather upholstery I'll hold you personally responsible! (joke)
Actually, that's very helpful thank you.

STay warm, all

Lara xxx
Jeni Babes

Post by Jeni Babes »

Hi guys

WOW...Jules - what a lot of stuff you have gone/are going through. If sheer determination was the factor in having babies your family would be bigger than the Waltons. I take my hat off to you and DH. Image

Amfy- thinking of you...good luck, am sure it will fly by when your back at work. That's handy that grid technique. It's so simple ! Will try that when i am ambivilent (sp) about next purchase! thanks

anna- Good luck for Frid...let us know how it goes. I have never been to ec either. Hoping 2006 brings that for us all.

The past two days i feel like i am going loopy Image.Emotionally i have been like a prized doberman crossed with a tazmanian she-devil, snapping everyones heads off and spawing myself Image. I keep apologising to DF then putting his back up again by saying something provoking. Where does it all come from?

The upshot of todays scan was i have 6 follies. 1 DEFUNCT, 1 too large, 3 between (10-15) and 1 at 8mm. my E2 hormone levels are still only that of 1 follie 490, but i am coasting on with the cetrotide until stimming day 13 ( wed) for another scan. Does this happen more with peri-menapausal and low follie count? i am trying to keep my feet on the ground and not loose faith. Have been told there is only a SLIM chance i wont be cancelled. Have told them about big j sending the boys round... now they are quaking in their boots. Thanks Jules :wink:

here's my update :

Kat - Fresh/donor cycle, hpt +ve!, blood test Tues 8th Nov
Nuala - fresh cycle, late Oct.
BigJ - TESE/donor egg cycle in Kiev, EC set for 23-24 Nov
Caroline - November FET postponed
Amfy - 2ww - test 25th November
Anna - cyst drain on 18th Nov, then start stimming
JackieT - start downregging 2/11 for FET
Heather - FET November sometime
Randa - Natural BDing until Jan, then first full IVF cycle
Lara - choosing tmt (IVF vs GIFT)
jen- Stimming day 13 scan and bloods

Love to you all
jen
xxx
donna99
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Posts: 105
Joined: Sun Oct 09, 2005 10:17 am

Post by donna99 »

hi guys,

hope you dont mind me posting on here, as i am 30, but would love to know if anyone can give me any advise on a few things....

ive been TTC for 4 .5 years now, mild endo....i cancelled IUI, 2 failed IUIs, 1 cancelled IVF, 2 failed IVF, i failed IVF FETs & the worst part a natural conception (which i know i should be grateful for) which ended in a miscarriage inbetween all the treatment. my clinic says i will get there but just need some luck! nice to hear but a killer waiting!!!

anyhow, due to go for yet another FET in new year....will be 4th IVF attempt, thought Id get there sooner with being 30, anyway, does anyone have advise on whether I should ask for further screening if this one fails???

eg, how do you get testing for killer cells/immune testing???

also, if i had a problem with these wouldnt it have shown up on one of my several hundred (it feels like it is by now!!!) routine blood tests for HCG, FSH, etc etc??????

sorry again to post here, but ive posted on the IVF site & had no luck so was advised to try you guys....

thanks so much & look forward to hearing from you!

good luck to anyone & everyone on TMT at moment & if youre cycling in the new year like me lets hope that next year is OUR YEAR, as we bloody deserve it !!!!!!!

lol donna99 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Jeni Babes

Post by Jeni Babes »

hi donna
sorry i don't have any knowledge of that to pass on to you.
Hope 'the wise ones' have some answers for you.
Good luck with the FET in the new year.

love
jenxxx
dancola
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Joined: Thu Apr 07, 2005 12:55 pm
Location: London

Post by dancola »

Donna, sorry to hear of your hard journey. Thought I’d reply on the killer cells front. I’ve been through 3 ICSI cycles so far (male factor) – first was a +ve but with an early m/c and the next 2 were both -ve. I have a perfect cycle and am a really good responder for my age (40) - I produce between 12 – 25 eggs and always get blastocysts. After my second cycle my clinic tested me for killer cells and anti-cardiolipins/coagulants (blood clotting issues). These are specific tests you’d need to ask for. I came up positive for higher NKC levels so took steroids and aspirin for my 3rd cycle but sadly it still didn’t work. I have also had a hysteroscopy at my request, although nothing was wrong. Physically I seem to be perfectly fine. For my FET we’ll be testing my progesterone levels because that’s all that we can think of now to test.Only good news is that I still have 7 frozen blastos for an FET.

I think I personally, in your shoes, would ask for NKC testing, if only to rule it out.
donna99
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Post by donna99 »

hi dancola,

thanks so much for your advice, i will ask for tests for killer cells...

what is a hysteroscopy? what does this test for? i have had a laparoscopy years ago.

many thanks & hope your dreams come true sooner than youd ever imagaine!

lol, donna99 xxxxxxxxxxxx
dancola
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Location: London

Post by dancola »

There’s more factual information on this site (under investigating infertility on the left hand side) but basically it cleans out your womb – a bit like a D&C. It also checks that nothing is in there that shouldn’t be (like fibroids etc). It apparently makes ET easier next time round because there are no blockages. I had also had a biopsy done to check there were no tumours etc. Had mine done under a general and recovery time was minimal (back at work the next day).
lara
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Location: London

Post by lara »

Dancola,

Have you heard of Foresight? A friend of mine who had 5 or 6 miscarriages, failed IVF attempts and God knows what got herself checked out and took all the vits/minerals that came up as lacking through her hair sample, then she got pg naturally. She's 46 now but I saw her the other day and she told me about friends of hers who had kids with own eggs at 47/8, and she was banging on at me about doing the Foresight check-up, so I looked them up on the web, rang them up (very nice) and you can do the whole thing by post (send off a hair sample and fill in forms for you and partner if you have one). There are certain things, like Selenium, that you absolutely HAVE to have if you're going to have a sucessful pg, and they test for it all and tell you exactly what to take. I take very good quality all-round supplements anyway, but it's worth a try.

Cheers,
Lara
dancola
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Post by dancola »

Not heard of Foresight, but there are other similar organisations (eg Marilyn Grenville) that offer something similar. Trouble is, our principal problem is male factor, so it would be near impossible for me to get pg naturally. I already take a great mix of vits (including selenium) so am covered on that front. You name it, I’ve taken it – Zita West’s, Marilyn Grenville’s. No, unfortunately I am either just unlucky, or it’s a progesterone problem (I always bleed 2 days before test date so the clinic reckon something causes my womb lining to collapse). Thanks for the info though.
lara
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Post by lara »

Hi chaps,

Dancola, you've obviously tried everything, I just hope you find out it's prog. and then you can fix it. Fingers and toes crossed for you.

I know the over 40s stream has been going for some months, and I was wondering if anyone knew how many people had got pg with own eggs? And how many of us are still trying that?

Sorry I get a bit confused about who's trying DE and who isn't. Of course I'm wondering whether I should use up my last few months of being under 44 on trying with my own eggs, which is what I'm planning to do.

Oh here I go again. Decisions decisions.

Thanks and hugs,

Lara xxx
dancola
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Post by dancola »

I’m only just 40, but plan to use my own eggs until the clinic tell me otherwise. I was the first to suggest DE to my consultant but he said my own eggs are fine and we always get grade 1 blastos, so there would be no advantage in my using DE. Never had my FSH tested but I guess as I produced 25 eggs last time round that I don’t have an issue there. However, I wouldn’t consider donor sperm (even though we’re male factor) – it would be just too hard for my husband to bear.
CarolineP
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Post by CarolineP »

Lara

I managed to achieve a pregnancy with my own egg and DH own sperm. Although I was a slow/minimal responder to meds we always managed 2 fertilised embryos each fresh cycle- putting more back or freezing was never an option for us.

We were prepared to continue treatment with our own 'supplies' until fertilisation failed or the clinic advised us otherwise.

CarolineP
Me 50 DH 57 - TTC 10 years
IVF July 04, Sept 04, Dec 04 all -ive
Mar 05 +ive - Amelia Leah born 30/11/05
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