OHSS-Ghost or anyone else

[amandago]

Hi all,

I am in the middle of my third and final IVF cycle. Up until this point I have not produced a huge number of follicles and my lining has been borderline (never great). My doctors believed that my leukemia medicine was inhibiting the IVF meds, causing a less than stellar response and preventing implantation.

I have been off my leukemia medicine for three months. It is out of my system. My doctors upped my Follistim to 450 and added 100 Clomid for the first 5 days. I am now looking at over 30 follicles and my estrogen today was 2735!

My doctors are concerned about OHSS and are telling me that I can not transfer this month most likley.

I have read that some women's estrogen reaches as high as 3000 or 4000 before they trigger. Do they all wait to transfer?

My leukemia doctor gave me permission to be off the meds for three months-I can not push it to 5 months.....I would have to go back on it and wait for up to a year before I could go off again to attempt the FET....sigh

They are also saying that I can not FET until the end of March-why would I have to wait so long?


Any advice or experience is greatly appreciated. Thanks so much!

[Ghost]

Hi all,

I am in the middle of my third and final IVF cycle. Up until this point I have not produced a huge number of follicles and my lining has been borderline (never great). My doctors believed that my leukemia medicine was inhibiting the IVF meds, causing a less than stellar response and preventing implantation.

I have been off my leukemia medicine for three months. It is out of my system. My doctors upped my Follistim to 450 and added 100 Clomid for the first 5 days. I am now looking at over 30 follicles and my estrogen today was 2735!

My doctors are concerned about OHSS and are telling me that I can not transfer this month most likley.

I have read that some women's estrogen reaches as high as 3000 or 4000 before they trigger. Do they all wait to transfer?

My leukemia doctor gave me permission to be off the meds for three months-I can not push it to 5 months.....I would have to go back on it and wait for up to a year before I could go off again to attempt the FET....sigh

They are also saying that I can not FET until the end of March-why would I have to wait so long?

Any advice or experience is greatly appreciated. Thanks so much!

Some clinics will cancel the transfer if the estradiol gets too high for their tastes, and they freeze all the embryos. 3000 is not all that high, but the OHSS risk starts to get significant at about that point. Freezing the embryos is not really bad news, as the success rates with frozens are pretty good these days. But many women take it as bad news. OHSS can still occur, but it will not last very long as the hCG from the trigger fades.

Sometimes they cancel the entire cycle, with no trigger given and no eggs retrieved. That avoids OHSS for sure, but the cycle is completely wasted.

I have no clue about the effect of "leukemia meds" on stimulation. Is that chemotherapy or something else?

[LYD10]

Hi all,

I am in the middle of my third and final IVF cycle. Up until this point I have not produced a huge number of follicles and my lining has been borderline (never great). My doctors believed that my leukemia medicine was inhibiting the IVF meds, causing a less than stellar response and preventing implantation.

I have been off my leukemia medicine for three months. It is out of my system. My doctors upped my Follistim to 450 and added 100 Clomid for the first 5 days. I am now looking at over 30 follicles and my estrogen today was 2735!

My doctors are concerned about OHSS and are telling me that I can not transfer this month most likley.

I have read that some women's estrogen reaches as high as 3000 or 4000 before they trigger. Do they all wait to transfer?

My leukemia doctor gave me permission to be off the meds for three months-I can not push it to 5 months.....I would have to go back on it and wait for up to a year before I could go off again to attempt the FET....sigh

They are also saying that I can not FET until the end of March-why would I have to wait so long?


Any advice or experience is greatly appreciated. Thanks so much!

with my first IUI my estrogen got into 7000 zone. the doc i was with at the time didnt pay close enough attention. luckily my body handled that level of estrogen. my 2nd doc, who took over the 1st one, told me to drink lots and lots of gatorade once he found out what my estrogen was. He was very surprised at how well i handled the high estrogen. this is usually not the case. for my IVF cycle my estrogen was allowed to get up to 5000 because at that point he knew that my body was able to handle it for some weird reason. my fresh cycle transfer didnt work though. maybe because the estrogen was so high or maybe for some other reason. i did a frozen one right after and it worked.

[margi26]

I don't understand all of your medical issues, but I can say that OHSS can be quite serious and really should be avoided if possible. If you get OHSS and then get pregnant it will exacerbate the condition and can put your health at risk. For most women who get it they are very uncomfortable, etc, (you can ask Rio and others that have recently had it.) But, it can also get more severe and cause hospitalization and other complications (as with me). I was pregnant following IVF which made me more sick, but ended up ectopic.

As I said, I don't fully know your condition and health, but please be careful. OHSS can be serious--even though it is rare to.

Regarding FET, I don't know why they would make you wait so long...maybe someone else can answer there.

Feel free to PM me if you have any other questions.

Best of luck!!

[ireneC]

I am not a medical expert but I have read from the webMD.com site that chemotherapy is the usual treatment for different types of leukemia. It is usually a combination of drugs which attack the cancer cells. Chemotherapy may help the patient to live longer even the cure is not possible.