Antral Follicle Count Ghost

[Nana11]

Ghost,
Does an Antral Follicle Count of 30 decrease the chances of a successful IVF cylce?

Does it increase the chance of hyperstimulation by a lot?
Thanks,

[Ghost]

Ghost,
Does an Antral Follicle Count of 30 decrease the chances of a successful IVF cylce?

Not if they do it right. If you are stimmed normally and triggered with Lupron, you should produce good eggs and have no OHSS. Many clinics like to freeze all embryos in that case, which is fine.

Does it increase the chance of hyperstimulation by a lot?
Thanks,

Not if they do it right. If they trigger you with Lupron, you are very unlikely to get OHSS. You might have some bloating, but it will fade away right after retrieval.

[Nana11]

Thanks for the answer ghost.
Actually, these numbers are my donor's (I wish they were mine!).
I ask because I'm very worried about hyperstimulation with such a large follicle count, which
would cost a lot of money and time. I asked the nurse and she said that they will use
an antagonist and lupron trigger protocol.
Do you think the risks are still high that the donor will hyperstimulate?

She is also very athletic, which worries me because I read that it might lower the success rates. Could this lower the success rate?

Thanks so much for answering my question.

[Ghost]

Thanks for the answer ghost.
Actually, these numbers are my donor's (I wish they were mine!).
I ask because I'm very worried about hyperstimulation with such a large follicle count, which
would cost a lot of money and time. I asked the nurse and she said that they will use
an antagonist and lupron trigger protocol.
Do you think the risks are still high that the donor will hyperstimulate?

She is also very athletic, which worries me because I read that it might lower the success rates. Could this lower the success rate?

Thanks so much for answering my question.

I did not realize it was a donor cycle. Lupron works great in donor cycles. No need to cancel for OHSS risk, or "coast" and risk ruining the eggs. Most studies suggest the eggs are just as good, maybe even a little better, with Lupron triggers, but with no need to cancel for OHSS risk.

[Nana11]

Ghost, Sorry for the confusion. I'm actually in the process of selecting an egg donor. I just learned today
that the donor we had selected has an antral follicle count of 62. On one side she has 26 and 36 on the other.
We were told last week that her AFC was 30 and today I learned that they gave me the wrong number.
What do you think of 62? Will this increase the chance for hyperstimulation and decrease the quality of the
eggs? It is such an expensive process that I fear selecting a donor that will produce poor quality eggs. should I worry
about the 62 count?
Thanks so much for answering my question.

[Ghost]

Ghost, Sorry for the confusion. I'm actually in the process of selecting an egg donor. I just learned today
that the donor we had selected has an antral follicle count of 62. On one side she has 26 and 36 on the other.
We were told last week that her AFC was 30 and today I learned that they gave me the wrong number.
What do you think of 62? Will this increase the chance for hyperstimulation and decrease the quality of the
eggs? It is such an expensive process that I fear selecting a donor that will produce poor quality eggs. should I worry
about the 62 count?
Thanks so much for answering my question.

We've had several that high. Estradiol gets well over 10,000. No OHSS yet, with the Lupron trigger.

[Nana11]

Ghost,
The cases that you had with AFC in the 60s, were they able to achieve live births? I'm worried about egg quality with numbers this high. Thanks.

[Ghost]

Ghost,
The cases that you had with AFC in the 60s, were they able to achieve live births? I'm worried about egg quality with numbers this high. Thanks.

For the most part, no problem.

It's possible the poor reputation for large cohorts is because (1) they often coast those patients and ruin much of the cohort, and (2) they may trigger when the lead follicle reaches a certain size, like 17mm, and most of the follicles are still very small (like 10-12mm). With a large cohort, especially in a donor, we like to let it grow a little longer.

[Nana11]

Ghost,
Thanks so much for your help.
It's such a confusing process and it's wonderful to have your advice.
My husband and I are still uncertain about what to do with this donor, but your advice is very helpful.