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Ovulation problems

Details the use of Tamoxifen in inducing ovulation in selected patients.

Ovulation induction by Tamoxifen

Tamoxifen is often used in inducing ovulation.

The drug Tamoxifen is chemically and functionally similar to clomiphene. Tamoxifen is usually prescribed to women who cannot tolerate clomiphene for one reason or another.

Tamoxifen should not be recommended to women with a personal or family history of blood clots, or to women who are known to have genetic defects that predispose them to thrombophilia to reduce the risk of developing blood clots with its serious consequences.

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While both clomiphene and tamoxifen are effective in inducing ovulation in properly selected patients (about 65-75%). They are less effective in establishing pregnancy (about 30-35%). If possible, the administration of clomiphene or of tamoxifen should be monitored by ultrasound scan because of the risk of multiple pregnancy. There is about a 10% risk of having twins and less than 1% of having triplets or more when using Tamoxifen.

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